eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| pituitary carcinoma | ||||
| Disease ID | 1063 |
|---|---|
| Disease | pituitary carcinoma |
| Definition | A pituitary tumor with subarachnoid, brain, or systemic metastasis. The diagnosis of a pituitary carcinoma requires evidence of metastatic disease, either outside the central nervous system (CNS) or as separate noncontiguous foci within the CNS. [DDD:spark, pmid:15741248] |
| Synonym | cancer of pituitary cancer of pituitary gland cancer of the pituitary cancer of the pituitary gland cancer, pituitary cancers, pituitary carcinoma of pituitary carcinoma of pituitary gland carcinoma of the pituitary carcinoma of the pituitary gland carcinoma pituitary carcinoma, pituitary carcinomas, pituitary pituitary cancer pituitary cancers pituitary carcinoma (disorder) pituitary carcinoma (morphologic abnormality) pituitary carcinomas pituitary gland adenocarcinoma pituitary gland cancer pituitary gland cancer, nos pituitary gland carcinoma pituitary gland--cancer |
| Orphanet | |
| DOID | |
| UMLS | C0346300 |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:4) C0001206 | acromegaly | 1 C0238463 | papillary thyroid carcinoma | 1 C0007115 | thyroid ca | 1 C0549473 | thyroid carcinoma | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:3) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:46) 801 | CALM1 | 1.141 | DISEASES 1813 | DRD2 | 2.084 | DISEASES 1813 | DRD2 | 1.887 | DISEASES 10938 | EHD1 | 1.788 | DISEASES 10938 | EHD1 | 1.41 | DISEASES 2159 | F10 | 1.832 | DISEASES 2195 | FAT1 | 1.451 | DISEASES 2773 | GNAI3 | 2.707 | DISEASES 2778 | GNAS | 3.657 | DISEASES 23560 | GTPBP4 | 1.352 | DISEASES 2987 | GUK1 | 2.807 | DISEASES 2987 | GUK1 | 2.43 | DISEASES 9146 | HGS | 2.264 | DISEASES 9146 | HGS | 1.887 | DISEASES 3451 | IFNA17 | 1.599 | DISEASES 3451 | IFNA17 | 1.222 | DISEASES 10989 | IMMT | 1.978 | DISEASES 10989 | IMMT | 1.6 | DISEASES 4221 | MEN1 | 3.898 | DISEASES 4221 | MEN1 | 2.076 | DISEASES 4553 | MT-TA | 2.705 | DISEASES 2516 | NR5A1 | 1.541 | DISEASES 2516 | NR5A1 | 1.164 | DISEASES 4905 | NSF | 1.508 | DISEASES 5230 | PGK1 | 2.613 | DISEASES 5230 | PGK1 | 2.236 | DISEASES 5449 | POU1F1 | 2.066 | DISEASES 5449 | POU1F1 | 1.689 | DISEASES 5573 | PRKAR1A | 3.071 | DISEASES 9232 | PTTG1 | 1.673 | DISEASES 9232 | PTTG1 | 1.296 | DISEASES 22931 | RAB18 | 2.502 | DISEASES 795 | S100G | 3.04 | DISEASES 6390 | SDHB | 1.764 | DISEASES 6390 | SDHB | 1.228 | DISEASES 27044 | SND1 | 1.828 | DISEASES 6752 | SSTR2 | 3.284 | DISEASES 6753 | SSTR3 | 1.769 | DISEASES 246744 | STH | 1.197 | DISEASES 7091 | TLE4 | 2.769 | DISEASES 7091 | TLE4 | 2.391 | DISEASES 10587 | TXNRD2 | 1.837 | DISEASES 10587 | TXNRD2 | 1.46 | DISEASES 7306 | TYRP1 | 1.412 | DISEASES 7306 | TYRP1 | 1.035 | DISEASES 6843 | VAMP1 | 2.493 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1063 |
|---|---|
| Disease | pituitary carcinoma |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:22) HP:0000873 | Diabetes insipidus HP:0000365 | Hearing impairment HP:0007987 | Progressive visual field defects HP:0100836 | Malignant neoplasm of the central nervous system HP:0000845 | Growth hormone excess HP:0012505 | Enlarged pituitary gland HP:0001251 | Ataxia HP:0100561 | Spinal cord lesion HP:0040075 | Hypopituitarism HP:0010514 | Hyperpituitarism HP:0011759 | Pituitary gonadotropic cell adenoma HP:0006767 | Pituitary prolactin cell adenoma HP:0003154 | Increased circulating ACTH level HP:0008291 | Pituitary corticotropic cell adenoma HP:0011760 | Pituitary growth hormone cell adenoma HP:0007739 | Mildly reduced visual acuity HP:0011763 | Pituitary carcinoma HP:0012377 | Hemianopsia HP:0000870 | Prolactin excess HP:0011442 | Abnormality of central motor function HP:0011762 | Pituitary thyrotropic cell adenoma HP:0002315 | Headache |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:5) HP:0002664 | Neoplasia | 1 HP:0002895 | Papillary thyroid carcinoma | 1 HP:0030731 | Carcinoma | 1 HP:0000845 | Acromegalic growth | 1 HP:0002890 | Thyroid carcinoma | 1 |
| Disease ID | 1063 |
|---|---|
| Disease | pituitary carcinoma |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:2) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:5) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0006767 | Pituitary prolactin cell adenoma | MP:0013383 | increased sebaceous gland adenoma incidence | greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any sebaceous gland, occurring in a specific population in a given time period |
| HP:0000845 | Growth hormone excess | MP:0003497 | insensitivity to parathyroid hormone | no changes in calcium homeostasis in response to endogenous or exogenous hormone |
| HP:0003154 | Increased circulating ACTH level | MP:0005661 | decreased circulating adrenaline level | less than the normal concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels |
| HP:0007987 | Progressive visual field defects | MP:0006149 | decreased visual acuity | loss of visual acuity or ability to distinguish small details |
| HP:0011760 | Pituitary growth hormone cell adenoma | MP:0003497 | insensitivity to parathyroid hormone | no changes in calcium homeostasis in response to endogenous or exogenous hormone |
Mapped by homologous gene(Total Items:13) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0100561 | Spinal cord lesion | MP:0013175 | bifurcated tail | the appearance of an abnormal division in the flexible elongated appendage located at the caudal end of the torso in many species |
| HP:0000873 | Diabetes insipidus | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0000845 | Growth hormone excess | MP:0014169 | decreased brown adipose tissue mass | decreased physical bulk or volume of brown adipose tissue |
| HP:0006767 | Pituitary prolactin cell adenoma | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
| HP:0011760 | Pituitary growth hormone cell adenoma | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
| HP:0007987 | Progressive visual field defects | MP:0014059 | abnormal photoreceptor connecting cilium morphology | any structural anomaly of the nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the retinal photoreceptor inner and outer segments |
| HP:0003154 | Increased circulating ACTH level | MP:0013565 | abnormal adrenal gland capsule morphology | any structural anomaly of the thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers |
| HP:0002315 | Headache | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0000870 | Prolactin excess | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
| HP:0000365 | Hearing impairment | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0001251 | Ataxia | MP:0020301 | short tongue | decreased length of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor |
| HP:0012377 | Hemianopia | MP:0013405 | increased circulating lactate level | greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase |
| HP:0040075 | Hypopituitarism | MP:0011495 | abnormal head shape | any anomaly in the characteristic surface outline or contour of a head of an organism |
| Disease ID | 1063 |
|---|---|
| Disease | pituitary carcinoma |
| Case | (Waiting for update.) |